Creatine: Even More Anabolic than You Thought

Using supplemental Creatine increases the amount of IGF-1 (Insulin Growth Like Factor 1) inside muscles. IGF-1 is a catalyst for Insulin and is produced by Growth Hormone. IGF-1 stimulates cell growth and lengthens cell life. IGF-1 can protect against cell and DNA damage by way of an enzyme family called AKT. AKT builds muscle and slows down cell death.

Creatine increases Growth Hormone production. Acute creatine loading enhances human growth hormone secretion.

Growth Hormone increases the amount of IGF-1. Correlations of growth hormone (GH) and insulin-like growth factor I (IGF-I): effects of exercise and abuse by athletes.

Effect of Creatine Supplementation and Resistance-Exercise Training on Muscle Insulin-Like Growth Factor in Young Adults
IJSNEM, 18(4), August 2008,

“These findings indicate that creatine supplementation during resistance-exercise training increases intramuscular IGF-I concentration in healthy men and women, independent of habitual dietary routine.”


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